Long-term Sabbatical

1) distribution of fitness effects of new mutations and 2) the rate of adaptive evolution

PI(s): Adam Eyre-Walker (University of Sussex)
Start Date: 1-Oct-2005
End Date: 30-Sep-2006
Keywords: mutation, evolutionary genetics, quantitative genetics, mathematical modeling

All organisms suffer from genetic mutation. At least some of these are harmful such that they reduce the probability of survival or fertility. But how harmful are these mutations? This is a question which lies at the heart of many problems, from how much genetic variation can be maintained in a population, to the evolution of sex and the genetic basis of human disease. The aim of the project is to develop methods to estimate the proportion of mutations which are strongly, mildly and weakly deleterious, and to apply these methods to a variety of data from humans and fruit flies

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